Piazza Navona is a public open space in Rome, Italy. It is built on the site of the Stadium of Domitian, built in the 1st century AD, and follows the form of the open space of the stadium. The ancient Romans went there to watch the agones ("games"), and hence it was known as "Circus Agonalis" ("competition arena"). It is believed that over time the name changed to in avone to navone and eventually to navona.

The Pantheon is a former Roman temple and, since 609 AD, a Catholic church (Basilica di Santa Maria ad Martyres) in Rome, on the site of an earlier temple commissioned by Marcus Agrippa during the reign of Augustus (27 BC – 14 AD). It was rebuilt by the emperor Hadrian and probably dedicated c. 126 AD. Its date of construction is uncertain, because Hadrian chose not to inscribe the new temple but rather to retain the inscription of Agrippa's older temple, which had burned down. The building is cylindrical with a portico of large granite Corinthian columns (eight in the first rank and two groups of four behind) under a pediment. A rectangular vestibule links the porch to the rotunda, which is under a coffered concrete dome, with a central opening (oculus) to the sky. Almost two thousand years after it was built, the Pantheon's dome is still the world's largest unreinforced concrete dome.

Piazza di Spagna ("Spanish Square"), at the bottom of the Spanish Steps, is one of the most famous squares in Rome, Italy. It owes its name to the Palazzo di Spagna, the seat of the Embassy of Spain to the Holy See. There is also the famed Column of the Immaculate Conception of the Blessed Virgin Mary.

Piazza del Popolo is a large urban square in Rome. The name in modern Italian literally means "People's Square", but historically it derives from the poplars (populus in Latin, pioppo in Italian) after which the church of Santa Maria del Popolo, in the northeast corner of the piazza, takes its name. The piazza lies inside the northern gate in the Aurelian Walls, once the Porta Flaminia of ancient Rome, and now called the Porta del Popolo. This was the starting point of the Via Flaminia, the road to Ariminum (modern-day Rimini) and the most important route to the north. At the same time, before the age of railroads, it was the traveller's first view of Rome upon arrival. For centuries, the Piazza del Popolo was a place for public executions, the last of which took place in 1826.

The Mausoleum of Hadrian, usually known as Castel Sant'Angelo is a towering cylindrical building in Parco Adriano. It was initially commissioned by the Roman Emperor Hadrian as a mausoleum for himself and his family. The building was later used by the popes as a fortress and castle, and is now a museum. The structure was once the tallest building in Rome.

Saint Peter's Square is a large plaza located directly in front of St. Peter's Basilica in Vatican City, the papal enclave inside Rome, directly west of the neighborhood (rione) of Borgo. Both the square and the basilica are named after Saint Peter, an apostle of Jesus considered by Catholics to be the first Pope. At the centre of the square is an ancient Egyptian obelisk, erected at the current site in 1586. Gian Lorenzo Bernini designed the square almost 100 years later, including the massive Doric colonnades, four columns deep, which embrace visitors in "the maternal arms of Mother Church". A granite fountain constructed by Bernini in 1675 matches another fountain designed by Carlo Maderno in 1613.

The Vatican Museums are the public museums of the Vatican City. They display works from the immense collection amassed by the Catholic Church and the papacy throughout the centuries, including several of the most renowned Roman sculptures and most important masterpieces of Renaissance art in the world. The museums contain roughly 70,000 works, of which 20,000 are on display, and currently employ 640 people who work in 40 different administrative, scholarly, and restoration departments.[ Pope Julius II founded the museums in the early 16th century.[The Sistine Chapel, with its ceiling and altar wall decorated by Michelangelo, and the Stanze di Raffaello (decorated by Raphael) are on the visitor route through the Vatican Museums. There are 24 galleries, or rooms, in total, with the Sistine Chapel, notably, being the last room visited within the Museum.