Savor the Flavors of Against the Grain Brewery & Public House

Getting There

• Car

  If you are traveling by car within the Bluegrass Region, you can use the interstate system to reach Against the Grain Brewery & Public House located at 401 E Main St, Louisville, KY 40202. From Lexington, take I-64 W for about 80 miles. Merge onto I-65 N toward Louisville. Take exit 136A for I-64 E toward Frankfort. Continue on I-64 E and take exit 1A for 2nd St. Follow signs for Main St and turn right onto E Main St. The brewery will be on your left. Parking is available nearby but may incur a fee depending on the location.

• Public Transportation

  For those using public transportation, you can take a Greyhound bus from various locations in the Bluegrass Region to Louisville. The bus station is located at 720 W Muhammad Ali Blvd, Louisville, KY 40203. From the bus station, you can either walk (approximately 15 minutes) or take a taxi/rideshare service to reach Against the Grain Brewery & Public House at 401 E Main St. Alternatively, check local transit services such as TARC for bus routes that may take you closer to the brewery.

• Taxi/Rideshare

  If you are already in downtown Louisville, you can easily use a taxi or rideshare service like Uber or Lyft to get to Against the Grain Brewery & Public House. Just enter the destination address (401 E Main St, Louisville, KY 40202) into the app, and you will receive an estimated fare. Ridesharing may cost between $7 to $15 depending on your pickup location.