Main Street Bed & Breakfast: A Historic Hannibal Retreat
Stay in a historic 1875 bank building in the heart of Hannibal, MO, steps from Mark Twain's legacy and the Mississippi Riverfront.
Experience the charm of Hannibal at the Main Street Bed & Breakfast, housed in a renovated 1875 bank building. Enjoy uniquely themed rooms, modern amenities, and a location steps away from Mark Twain's legacy and the Mississippi River.
A brief summary to Main Street Bed & Breakfast
- 201 N Main St, Hannibal, Missouri, 63401, US
- +1573-406-3892
- Visit website
Local tips
- Book directly with the B&B for the best rates and personalized service.
- Request a room with a jetted tub for a relaxing soak after a day of exploring.
- Take advantage of the B&B's central location and walk to nearby attractions, restaurants, and shops.
- Enjoy the complimentary continental breakfast, snacks, and beverages provided.
Getting There
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Walking
From the Mark Twain Boyhood Home and Museum, walk north on Main Street for about 2 minutes (0.1 miles). The Main Street Bed & Breakfast will be on your left, across from The Brick Oven Italian restaurant. No costs involved.
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Public Transport
From the Hannibal bus station at 4811 McMasters Ave, take the OATS Transit in-town service. The ride to downtown Hannibal will cost $2.00. Get off near Main Street and walk a short distance to 201 N Main St. Call 660-415-0901 to schedule a ride.
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Taxi
From the Hannibal Regional Airport, a taxi ride to Main Street Bed & Breakfast will cost approximately $20-$25. The ride is about 15 minutes, depending on traffic. Taxi services are available at the airport.
Discover more about Main Street Bed & Breakfast
Iconic landmarks you can’t miss
Main Street Bed & Breakfast
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Stay in a historic 1875 bank building in the heart of Hannibal, MO, steps from Mark Twain's legacy and the Mississippi Riverfront.
Chocolaterie Stam
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Indulge in handcrafted chocolates, truffles, and gelato at Chocolaterie Stam in historic Hannibal, Missouri. A sweet treat for all ages!
The Travelers Rooming House
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Experience Hannibal's history and charm at The Travelers Rooming House, a unique and cozy lodging in the heart of downtown.
Twain on Main
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Experience the heart of 'America's Hometown' at Twain on Main, where history and community converge in Hannibal, Missouri.
Mississippi Marketplace, LLC
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Discover unique Missouri-made foods, gifts, and kitchen supplies in a charming, historic general store in Hannibal's downtown.
Native American Trading Co
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Explore authentic Native American crafts and culture in historic Hannibal, Missouri. Discover unique jewelry, apparel, and gifts at this must-see shop.
Historic Downtown Hannibal
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Discover the charm of Mark Twain's boyhood home in Historic Downtown Hannibal, a vibrant blend of history, culture, and Mississippi River views.
Hannibal Tour Company
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Discover the historic charm and literary legacy of Hannibal, Missouri, with immersive tours from the Hannibal Tour Company, your guide to Mark Twain's hometown.
Bluff City Theater
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Experience professional theater in an intimate, historic setting in downtown Hannibal, Missouri. Literary works come to life!
Center Street Landing - Mark Twain Riverboat
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Cruise the Mississippi on the Mark Twain Riverboat in Hannibal, MO, and experience the river that inspired a literary legend.
Hawthorn by ButterBee
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Discover the artistry of tattooing at Hawthorn by ButterBee in Hannibal, Missouri—where each design tells a story.
Ole Wolfhound Pub
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Experience authentic Irish fare, spirits, and live music in a cozy, traditional pub setting in historic Hannibal, Missouri.
La Azotea Cocktail Lounge
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Experience nostalgic charm and creative cocktails at La Azotea Cocktail Lounge, a unique Hannibal bar in a cozy, antique-filled historic building.
Aunt Polly's Treasures
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Discover vintage charm at Aunt Polly's Treasures in Hannibal, MO: a nostalgic collection of antiques and collectibles for all ages.
B&B Theatres Hannibal Main Street Cinema 8
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Enjoy the latest movies in comfort at Hannibal's modern cinema, located in the heart of historic downtown.
Unmissable attractions to see
The Mark Twain Boyhood Home Museum Gallery
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Explore the Mark Twain Boyhood Home Museum Gallery in Hannibal, Missouri, and discover the roots of America's beloved author and his timeless tales.
Mark Twain Museum Gallery
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Journey through the life and literary legacy of Mark Twain at the Mark Twain Museum Gallery in Hannibal, Missouri, and discover the stories that shaped a nation.
Becky Thatcher House
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Discover the charm of the Becky Thatcher House in Hannibal, Missouri, where Mark Twain's literary inspirations come to life through history and heritage.
Mark Twain Riverboat
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Explore the iconic Mark Twain Riverboat, where history meets adventure on the scenic Mississippi River in Hannibal, Missouri.
Nipper Park
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Discover tranquility and adventure at Nipper Park, a stunning natural retreat in Hannibal, MO, perfect for outdoor enthusiasts and families alike.
Jim's Journey: The Huck Finn Freedom Center
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Discover the profound journey of freedom at Jim's Journey: The Huck Finn Freedom Center, a unique museum celebrating Mark Twain's legacy in Hannibal, Missouri.
Mississippi Mind Trap-Escape Room
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Experience the thrill of adventure at Mississippi Mind Trap, Hannibal's premier escape room destination that promises fun, excitement, and unforgettable memories.
Mark Twain Memorial Lighthouse
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Experience the historical charm and breathtaking views at Mark Twain Memorial Lighthouse, a must-see attraction in Hannibal, Missouri.
Molly Brown Birthplace Museum
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Explore the inspiring story of 'The Unsinkable Molly Brown' at her birthplace museum, a must-visit destination in Hannibal, Missouri.
Rockcliffe Mansion
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Explore the elegance of Rockcliffe Mansion, a captivating museum and bed & breakfast in Hannibal, Missouri, rich in history and architectural beauty.
Lovers' Leap
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Experience breathtaking views and rich history at Lovers' Leap in Hannibal, Missouri, a must-visit destination for all nature lovers and adventurers.
Welcome To Missouri Sign
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Experience the warmth of Midwestern charm at the Welcome to Missouri Sign in Hannibal, a delightful photo stop rich in culture and history.
Sodalis Preserve
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Discover the serene beauty of Sodalis Preserve in Hannibal, MO—an ideal destination for nature lovers and outdoor enthusiasts seeking tranquility.
Riverview Park
2.0 km
Discover the serene beauty of Riverview Park in Hannibal, where lush landscapes and stunning river views await your visit.
Mark Twain Cave
3.2 km
Discover the enchanting Mark Twain Cave in Hannibal, Missouri—where history and adventure meet beneath the earth's surface.
Essential places to dine
Rumor Has It... Bar & Grill
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Discover the lively ambiance of Rumor Has It... Bar & Grill in Hannibal - where great food meets sports excitement!
The Brick Oven
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Experience delightful family-friendly dining at The Brick Oven in Hannibal - where gourmet pizza meets warm hospitality.
Java Jive
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Discover the delightful flavors of Java Jive in Hannibal—where every cup tells a story and every bite is a treat!
Greater Days
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Experience authentic American cuisine at Greater Days in Hannibal – where hearty meals meet warm hospitality.
Finn's Food & Spirits
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Discover delightful American cuisine at Finn's Food & Spirits in Hannibal - where great food meets warm hospitality.
Frozen Sippi’s LLC
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Experience the unique charm of Frozen Sippi's LLC in Hannibal—where handcrafted cocktails meet used books and fun games.
Becky Thatcher's Diner
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Experience hearty breakfasts and warm hospitality at Becky Thatcher's Diner in Hannibal - where every meal tells a story.
Rio Grande
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Discover authentic Mexican cuisine at Rio Grande in Hannibal, MO - where every meal is a celebration of flavor and culture.
Mark Twain Dinette: Maid-Rite Restaurant and Diner
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Savor classic American comfort food at Mark Twain Dinette in Hannibal - your destination for delicious meals and local history.
Friendship Brewing Company- Hannibal
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Sidekick's BBQ & Sweets
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Experience authentic Missouri barbecue at Sidekick's BBQ & Sweets - where smoky flavors meet sweet delights in Hannibal.
LaBinnah Bistro
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Experience culinary excellence at LaBinnah Bistro in Hannibal, MO – where local flavors meet creative cuisine for an unforgettable dining adventure.
Broadway Bar N Grill
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Experience delicious American cuisine at Broadway Bar N Grill in Hannibal - where family-friendly dining meets vibrant atmosphere.
Hot Stuff Pizza
1.1 km
Experience mouthwatering pizzas made with fresh ingredients at Hot Stuff Pizza in Hannibal, MO - a must-visit culinary delight!
Lil O Hickory Hut
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Discover the rich flavors of southern barbecue at Lil O Hickory Hut in Hannibal, MO – where every bite tells a story.
Markets, malls and hidden boutiques
Country Shop
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Discover unique gifts and local treasures at the Country Shop in Hannibal, Missouri. A charming destination for every traveler.
The Travelers Boutique
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Explore The Travelers Boutique in Hannibal, MO, for unique gifts and local crafts that tell the story of this charming town.
Cornelia Mercantile
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Explore Cornelia Mercantile in Hannibal, MO for unique antiques and vintage treasures that capture the essence of timeless charm and history.
Danni Nicole's
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Explore Danni Nicole's in Hannibal, MO – your go-to women's clothing store for stylish apparel and accessories at reasonable prices.
Southwestern Souvenirs
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Explore Southwestern Souvenirs in Hannibal, MO - your destination for authentic local crafts, unique gifts, and a taste of the Southwest.
Raconteur Society booth
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Explore the charm of Hannibal, Missouri, at Raconteur Society - a gift shop filled with unique, locally crafted treasures and artistic creations.
Savannah's
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Discover unique and stylish furniture at Savannah's in Hannibal, Missouri, where every piece tells a story.
Lydia's Cabinet of Curiosities
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NobleWares
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Explore NobleWares in Hannibal, Missouri, where collectibles, cutlery, and Western apparel merge to create a unique shopping experience.
Jill's Hand Picked Treasures and John's Soda Pop Shop
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Discover unique antiques and nostalgic sodas at Jill's Hand Picked Treasures and John's Soda Pop Shop in Hannibal, MO, the perfect blend of charm and history.
CoolByke Bicycle Shop & Rentals
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Discover Hannibal, MO, on two wheels with CoolByke Bicycle Shop & Rentals, your go-to spot for bike rentals, repairs, and local adventures.
From Jank To Swank
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Explore the charm of vintage treasures at From Jank To Swank, Hannibal's premier antique store for unique finds and timeless decor.
Mark Twain Book & Gift Shop
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Ayers Pottery
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Becky Thatcher Book Shop
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Essential bars & hidden hideouts
Main Street Wine Stoppe
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Tipsy Bricks Bar
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Rookie's Sports Bar
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Experience the excitement at Rookie's Sports Bar in Hannibal, MO, where sports, cocktails, and camaraderie come together for an unforgettable night out.
Sportsman's Bar
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Experience the cozy charm of Sportsman's Bar, a local favorite in Hannibal, MO, perfect for unwinding with drinks, darts, and lively entertainment.
The WaterHole
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Discover The WaterHole in Hannibal, a vibrant bar offering a cozy ambiance and a fantastic selection of drinks, perfect for relaxation after a day of exploration.
Hannibal Arms
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Experience the charm of Hannibal, Missouri, at the welcoming Hannibal Arms Pub, where great food and local brews await.
WEST END BAR & GRILL
4.1 km
Discover the vibrant flavors of Hannibal at West End Bar & Grill, where delicious food and a lively atmosphere await every visitor.
CJ'S bar
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Discover the warmth of CJ'S Bar in New Canton, where friendly faces and great drinks create unforgettable moments.
Copperhead Taverns
26.2 km
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The Lantern
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Discover The Lantern in Barry, Illinois - a cozy bar with a warm atmosphere and a diverse drink menu perfect for unwinding after a day of exploration.
Tiny's Place
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Experience the warmth and charm of Tiny's Place, Barry's favorite bar for delightful drinks and a welcoming atmosphere among locals and travelers alike.
Rustic Oak Cabin Steakhouse
35.3 km
Delight in the savory offerings of Rustic Oak Cabin Steakhouse, where exquisite steaks meet a charming rustic ambiance in Perry, Missouri.
Michael Tavern
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Straight Home
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Big John's corner
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