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Main Street Bed & Breakfast: A Historic Hannibal Retreat

Stay in a historic 1875 bank building in the heart of Hannibal, MO, steps from Mark Twain's legacy and the Mississippi Riverfront.

★★★★★4.8 (76)

Experience the charm of Hannibal at the Main Street Bed & Breakfast, housed in a renovated 1875 bank building. Enjoy uniquely themed rooms, modern amenities, and a location steps away from Mark Twain's legacy and the Mississippi River.

Plan your visit

A brief summary to Main Street Bed & Breakfast

Opening times, essentials, and a few local tips gathered into one calmer, easier-to-scan planning section.

Plan your visit

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201 N Main St, Hannibal, Missouri, 63401, US

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    Getting There

    Walking

    From the Mark Twain Boyhood Home and Museum, walk north on Main Street for about 2 minutes (0.1 miles). The Main Street Bed & Breakfast will be on your left, across from The Brick Oven Italian restaurant. No costs involved.

    Public Transport

    From the Hannibal bus station at 4811 McMasters Ave, take the OATS Transit in-town service. The ride to downtown Hannibal will cost $2.00. Get off near Main Street and walk a short distance to 201 N Main St. Call 660-415-0901 to schedule a ride.

    Taxi

    From the Hannibal Regional Airport, a taxi ride to Main Street Bed & Breakfast will cost approximately $20-$25. The ride is about 15 minutes, depending on traffic. Taxi services are available at the airport.

    Local tips

    Book directly with the B&B for the best rates and personalized service.
    Request a room with a jetted tub for a relaxing soak after a day of exploring.
    Take advantage of the B&B's central location and walk to nearby attractions, restaurants, and shops.
    Enjoy the complimentary continental breakfast, snacks, and beverages provided.

    Discover more about Main Street Bed & Breakfast

    Nestled in the heart of Hannibal's historic downtown, the Main Street Bed & Breakfast offers a unique and intimate lodging experience. Housed in a renovated bank building dating back to 1875, this B&B features three uniquely themed guest rooms, each with private bathrooms, jetted tubs, and separate showers. Choose from the Arts and Crafts Suite, the Renaissance Suite, or the Safari Suite for a memorable stay.The Main Street Bed & Breakfast is ideally located for exploring Hannibal's top attractions. Just steps away, you'll find the Mark Twain Boyhood Home and Museum, Planters Barn Theater, and the Mississippi Riverfront. Enjoy a leisurely stroll along Main Street, browsing the charming shops, restaurants, and entertainment venues.Owners Michael and Pam Ginsberg, originally from Denver, Colorado, relocated to Hannibal in 1988 and remodeled the old F&M Bank building in 2000. They created a welcoming space for guests, combining historic charm with modern amenities. Mark Twain himself visited this building in 1903, adding to its historical significance.
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    File:Mark Twain Boyhood Home 1.jpg - Wikimedia Commons

    More about Hannibal

    Discover Hannibal, Missouri: A picturesque river town steeped in Mark Twain's legacy, offering historic charm, scenic beauty, and vibrant cultural experiences.

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